5-氯-3-乙基N-[2-(4-哌啶-1-基)苯基乙基]-1H-吲哚-2-甲酰胺
Org 27569
CAS: 868273-06-7
Molecular Formula: C24H28ClN3O
5-氯-3-乙基N-[2-(4-哌啶-1-基)苯基乙基]-1H-吲哚-2-甲酰胺 - Names and Identifiers
5-氯-3-乙基N-[2-(4-哌啶-1-基)苯基乙基]-1H-吲哚-2-甲酰胺 - Physico-chemical Properties
| Molecular Formula | C24H28ClN3O |
| Molar Mass | 409.95 |
| Density | 1.218±0.06 g/cm3(Predicted) |
| Boling Point | 660.3±55.0 °C(Predicted) |
| Solubility | H2O: <2mg/mL |
| Appearance | powder |
| Color | white |
| pKa | 14.87±0.30(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD11045300 |
| Use | Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, which induces changes in CB1 receptor state by enhancing the affinity of agonists and reduces the affinity of inverse agonists. |
| In vitro study | Org 27569 is an allosteric modulator of the CB1 cannabinoid receptor. It significantly increases the binding of the CB1 receptor to the agonist and significantly reduces the specific binding of the CB1 receptor to the inverse agonist. Org 27569 induces CB1 to bind agonists with high affinity, receptor internalization, and downstream ERK phosphorylation. Allosteric ligand Org 27569 promotes the binding of agonists to CB1, but blocks conformational changes in tm6. The Org 27569 decoy receptors bind to different agonists, but do not signal a conformational state. Org 27569 is an allosteric modulator of the CB1 cannabinoid receptor. It significantly increases the binding of the CB1 receptor to the agonist and significantly reduces the specific binding of the CB1 receptor to the inverse agonist. Org 27569 induces CB1 to bind agonists with high affinity, receptor internalization, and downstream ERK phosphorylation. Allosteric ligand Org 27569 promotes the binding of agonists to CB1, but blocks conformational changes in tm6. The Org 27569 decoy receptors bind to different agonists, but do not signal a conformational state. |
5-氯-3-乙基N-[2-(4-哌啶-1-基)苯基乙基]-1H-吲哚-2-甲酰胺 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
5-氯-3-乙基N-[2-(4-哌啶-1-基)苯基乙基]-1H-吲哚-2-甲酰胺 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.439 ml | 12.197 ml | 24.393 ml |
| 5 mM | 0.488 ml | 2.439 ml | 4.879 ml |
| 10 mM | 0.244 ml | 1.22 ml | 2.439 ml |
| 5 mM | 0.049 ml | 0.244 ml | 0.488 ml |
Last Update：2024-01-02 23:10:35
5-氯-3-乙基N-[2-(4-哌啶-1-基)苯基乙基]-1H-吲哚-2-甲酰胺 - Reference Information
| Biological activity | Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, which induces changes in CB1 receptor state by enhancing the affinity of agonists and reduces the affinity of reverse agonists. Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, which induces changes in CB1 receptor state by enhancing the affinity of agonists and reduces the affinity of inverse agonists. |
| In vitro study | Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptors to agonists and significantly reduces the specific binding of CB1 receptors to inverse agonists. Org 27569 induces CB1 to bind agonists with high affinity, receptor internalization, and downstream ERK phosphorylation. The allosteric ligand Org 27569 promotes the binding of the agonist to CB1, but blocks the conformational change in TM6. Org 27569 trapping receptors bind to different agonists, but there is no signal of conformational state. Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptors to agonists and significantly reduces the specific binding of CB1 receptors to inverse agonists. Org 27569 induces CB1 to bind agonists with high affinity, receptor internalization, and downstream ERK phosphorylation. The allosteric ligand Org 27569 promotes the binding of the agonist to CB1, but blocks the conformational change in TM6. Org 27569 trapping receptors bind to different agonists, but there is no signal of conformational state. |
| Features | The trap receptor binds to different agonists, but there is no signal of conformational state. |
| target | TargetValue CB1 |
| Target | Value |
Last Update：2024-04-09 21:31:59
![5-氯-3-乙基N-[2-(4-哌啶-1-基)苯基乙基]-1H-吲哚-2-甲酰胺](http://res.chembk.com/assets/images/structure/311334.gif)
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Product Name: Org 27569 Visit Supplier Webpage Request for quotationCAS: 868273-06-7
Tel: 609-228-6898
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tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: ORG-27569 Visit Supplier Webpage Request for quotationCAS: 868273-06-7
Tel: +16314854226
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Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
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Product Name: Org 27569 Visit Supplier Webpage Request for quotationCAS: 868273-06-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Org 27569 Visit Supplier Webpage Request for quotationCAS: 868273-06-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Org 27569 Visit Supplier Webpage Request for quotation
CAS: 868273-06-7
Tel: 18301782025
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CAS: 868273-06-7
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View History
5-氯-3-乙基N-[2-(4-哌啶-1-基)苯基乙基]-1H-吲哚-2-甲酰胺
1-(5-苯基异噁唑-3-基)环丙烷-1-羧酸
2-(4-氨基四氢吡喃-4-基)乙酰胺盐酸盐
2-氨基-5,6-二氢-4H-环戊二烯并[B]噻吩-3-甲酰胺
BISPHENOLADIGLYCIDYLETHERDIHYDRATE
芦荟大黄素8-0葡萄糖苷
4-Anisidine-2--hydroxyethyl sulfone sulfate ester
1-METHYL-2,3-PYRROLIDINEDIONE
TERT-BUTYL (3R,4S)-3-AMINO-4-METHYLPYRROLIDINE-1-CARBOXYLATE
GLUTATHIONE-S-TRANSFERASE SCHISTOSOMA JAPONICUM
1-(5-苯基异噁唑-3-基)环丙烷-1-羧酸
2-(4-氨基四氢吡喃-4-基)乙酰胺盐酸盐
2-氨基-5,6-二氢-4H-环戊二烯并[B]噻吩-3-甲酰胺
BISPHENOLADIGLYCIDYLETHERDIHYDRATE
芦荟大黄素8-0葡萄糖苷
4-Anisidine-2--hydroxyethyl sulfone sulfate ester
1-METHYL-2,3-PYRROLIDINEDIONE
TERT-BUTYL (3R,4S)-3-AMINO-4-METHYLPYRROLIDINE-1-CARBOXYLATE
GLUTATHIONE-S-TRANSFERASE SCHISTOSOMA JAPONICUM